Kelland L (2004) “Of mice and men”: values and liabilities of the athymic nude mouse model in anticancer drug development. Keil T, Liu D, Lloyd M, Coombs W, Moffat J, Visalli R (2020) DNA encapsidation and capsid assembly are underexploited antiviral targets for the treatment of herpesviruses.
#CB 17 SCID SKIN#
Jarosinski KW, Carpenter JE, Buckingham EM, Jackson W, Knudtson K, Moffat JF, Kita H, Grose C (2018) Cellular stress response to varicella-zoster virus infection of human skin includes highly elevated interleukin-6 expression. Ito M, Hiramatsu H, Kobayashi K, Suzue K, Kawahata M, Hioki K, Ueyama Y, Koyanagi Y, Sugamura K, Tsuji K (2002) NOD/SCID/γ c null mouse: an excellent recipient mouse model for engraftment of human cells. Haberthur K, Meyer C, Arnold N, Engelmann F, Jeske DR, Messaoudi I (2014) Intrabronchial infection of rhesus macaques with simian varicella virus results in a robust immune response in the lungs. Gobbi A, Stoddart CA, Locatelli G, Santoro F, Bare C, Linquist-Stepps V, Moreno ME, Abbey NW, Herndier BG, Malnati MS, McCune JM, Lusso P (2000) Coinfection of SCID-hu Thy/Liv mice with human herpesvirus 6 and human immunodeficiency virus type 1. Gobbi A, Stoddart CA, Malnati MS, Locatelli G, Santoro F, Abbey NW, Bare C, Linquist-Stepps V, Moreno MB, Herndier BG, Lusso P, McCune JM (1999) Human herpesvirus 6 (HHV-6) causes severe thymocyte depletion in SCID-hu Thy/Liv mice. Antiviral Res 110:10–19ĭittmer D, Stoddart C, Renne R, Linquist-Stepps V, Moreno ME, Bare C, McCune JM, Ganem D (1999) Experimental transmission of Kaposi’s sarcoma-associated herpesvirus (KSHV/HHV-8) to SCID-hu Thy/Liv mice. Arch Dermatol Res 302:47–55ĭe C, Liu D, Zheng B, Singh US, Chavre S, White C, Arnold RD, Hagen FK, Chu CK, Moffat JF (2014) Beta-l-1- uracil (l-BHDU) prevents varicella-zoster virus replication in a SCID-Hu mouse model and does not interfere with 5-fluorouracil catabolism. J Virol 82:5825–5834Ĭhiner E, Ballester I, Betlloch I, Blanquer J, Aguar MC, Blanquer R, Fernandez-Fabrellas E, Andreu AL, Briones M, Sanz F (2010) Varicella-zoster virus pneumonia in an adult population: has mortality decreased? Scand J Infect Dis 42:215–221Ĭoolen NA, Schouten KC, Middelkoop E, Ulrich MM (2010) Comparison between human fetal and adult skin. Front Microbiol 9:2935Ĭhe X, Reichelt M, Sommer MH, Rajamani J, Zerboni L, Arvin AM (2008) Functions of the ORF9-to-ORF12 gene cluster in varicella-zoster virus replication and in the pathogenesis of skin infection. Nature 363:728–732īuckingham EM, Girsch J, Jackson W, Cohen JI, Grose C (2018) Autophagy quantification and STAT3 expression in a human skin organ culture model for innate immunity to herpes zoster. J Virol 77:5964–5974īonyhadi ML, Rabin L, Salimi S, Brown DA, Kosek J, McCune JM, Kaneshima H (1993) HIV induces thymus depletion in vivo. Proc Natl Acad Sci U S A 107:282–287īesser J, Sommer MH, Zerboni L, Bagowski CP, Ito H, Moffat J, Ku CC, Arvin AM (2003) Differentiation of varicella-zoster virus ORF47 protein kinase and IE62 protein binding domains and their contributions to replication in human skin xenografts in the SCID-hu mouse. Methods Mol Biol 1185:267–278īerarducci B, Rajamani J, Zerboni L, Che X, Sommer M, Arvin AM (2010) Functions of the unique N-terminal region of glycoprotein E in the pathogenesis of varicella-zoster virus infection. Sci Rep 6:34164Īryee KE, Shultz LD, Brehm MA (2014) Immunodeficient mouse model for human hematopoietic stem cell engraftment and immune system development. Taconic Biosciences, Inc.Īrnold N, Girke T, Sureshchandra S, Nguyen C, Rais M, Messaoudi I (2016) Genomic and functional analysis of the host response to acute simian varicella infection in the lung. Virology 435:14–28Īnonymous (2021) Important factors for experimental success in xenograft host selection. Front Immunol 12:636775Īkkina R (2013) New generation humanized mice for virus research: comparative aspects and future prospects. Abeynaike S, Paust S (2021) Humanized mice for the evaluation of novel HIV-1 therapies.